C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/16 (2006.01) C12N 15/63 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2371195
The use of an erythroid cell which is substantially undifferentiated but which is capable of expressing a heterologous protein under the control of a globin promoter thereof, in an assay in which said protein interacts with an endogenous signalling cascade of said cell and said interaction is detected. In general, such assays will be functional assays. The production of suitable erythroid cells as well as cells useful in this way are also described and claimed.
Utilisation d'une cellule érythrocytaire sensiblement indifférenciée mais capable d'exprimer une protéine hétérologue sous la commande de son promoteur de globine dans une méthode de dosage, dans laquelle ladite protéine joue un rôle interactif avec une cascade de signalisation endogène de ladite cellule, consistant à détecter cette interaction. En général, ces méthodes de dosage seront des méthodes fonctionnelles. L'invention concerne également la préparation de cellules érythrocytaires adéquates, ainsi que des cellules utiles à cet effet.
Blythe Judith Lesley
Dunbar Stuart John
Earley Fergus Gerard Paul
Suner Marie-Marthe
Windass John David
Fetherstonhaugh & Co.
Syngenta Limited
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