C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/867 (2006.01) A61K 39/00 (2006.01) A61K 39/155 (2006.01) A61K 39/165 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12N 15/86 (2006.01) C07K 14/115 (2006.01) C07K 14/12 (2006.01)
Patent
CA 2673262
The present invention relates to recombinant cells as well as to methods for the generation of non-segmented negative-sense single- stranded RNA viruses (NNV or mononegavirales) from cloned deoxyribonucleic acid (cDNA), especially from measles virus and in particular from attenuated strains such as those approved for vaccination, in particular from the attenuated Schwarz measles virus and various recombinant Schwarz measles-based viruses expressing heterologous sequences. Such rescued viruses can be used, after amplification, as vaccines for immunization against measles and/or against the heterologous peptides or proteins expressed.
La présente invention porte sur des cellules recombinantes ainsi que sur des procédés pour la génération de virus à ARN simple brin de sens négatif non segmenté (NNV ou mononégaviraux) à partir d'un acide désoxyribonucléique cloné (ADNc), notamment à partir du virus de la rougeole et, en particulier, à partir de souches atténuées telles que celles approuvées pour la vaccination, en particulier à partir du virus de la rougeole de Schwarz atténué et de divers virus à base de rougeole de Schwarz recombinants exprimant des séquences hétérologues. De tels virus rescapés peuvent être utilisés, après amplification, en tant que vaccins pour une immunisation contre la rougeole et/ou contre les peptides et protéines hétérologues exprimés.
Charneau Pierre
Jacob Yves
Tangy Frederic
Centre National de La Recherche Scientifique
Institut Pasteur
Robic
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