C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 38/16 (2006.01) C07K 14/725 (2006.01) C07K 14/73 (2006.01) C07K 14/735 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2195653
Disclosed is a method of treating HIV in a mammal involving administering to the mammal an effective amount of therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection. Also disclosed are cells which express these CD4 receptors and DNA and vectors encoding the receptors.
Procédé de traitement du VIH chez un mammifère, qui consiste à administrer à ce mammifère une quantité thérapeutiquement efficace de cellules thérapeutiques exprimant un récepteur chimérique protéique membranaire. Ledit récepteur comprend une partie extracellulaire qui comporte un fragment de CD4 capable de reconnaître spécifiquement la cellule infectée par le VIH et de se lier à cette dernière, mais qui n'induit pas l'infection due au VIH. Des cellules qui expriment ces récepteurs CD4 et de l'ADN et des vecteurs qui codent lesdits récepteurs sont également décrits.
Banapour Babak
Kolanus Waldemar
Romeo Charles
Seed Brian
Smart & Biggar
The General Hospital Corporation
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