C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 5/0793 (2010.01) A01K 67/027 (2006.01) A61K 45/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2683114
Disclosed are mammalian neuronal cells expressing alpha synuclein as well as methods of screening to identify compounds that decrease toxicity induced by alpha synuclein expression. Compounds identified by such screens can be used to treat or prevent synucleinopathies such as Parkinson's disease, familial Parkinson's disease, Lewy body disease, the Lewy body variant of Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, or the Parkinsonism-dementia complex of Guam.
L'invention concerne des cellules nerveuses de mammifères exprimant l'alpha-synucléine ainsi que des méthodes de criblage permettant d'identifier des composés qui diminuent la toxicité induite par l'expression de l'alpha-synucléine. Les composés identifiés à l'aide de tels cribles peuvent être utilisés pour traiter ou prévenir les synucléinopathies telles que la maladie de Parkinson, la maladie de Parkinson familiale, la maladie à corps de Lewy, la variante à corps de Lewy de la maladie d'Alzheimer, la démence avec corps de Lewy, l'atrophie multisystématisée, ou le complexe parkinsonisme-démence de Guam.
Liang Feng
Foldrx Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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