Cells expressing immunoregulatory molecules and uses therefor

Details Cells expressing immunoregulatory molecules and uses therefor Cells expressing immunoregulatory molecules and uses therefor

A - Human Necessities

61

K

A61K 48/00 (2006.01) A01K 67/027 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 14/74 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2341755

Compositions comprising genetically modified cells which express at least one immunoregulatory molecule and methods for using the genetically modified cells are described. The immunoregulatory molecule expressed by the cell(s) are capable of inhibiting T cell activation and/or natural killer cell-mediated immune response against the cell upon transplantation into a recipient subject. The cells of the invention can express an immunoregulatory molecule on the surface of the cells or secrete the immunoregulatory molecule in soluble form. The cells of the invention can be transplanted into a recipient subject such that immune rejection of the cell is inhibited. In addition, non- human transgenic animals which contain cells which are genetically modified to express at least one immunoregulatory molecule are described.

La présente invention concerne des compositions renfermant des cellules génétiquement modifiées qui expriment au moins une molécule immuno-régulatrice, et des méthodes d'utilisation desdites cellules. La molécule immuno-régulatrice exprimée par la ou les cellule(s) est capable d'inhiber l'activation de cellules T et/ ou la réponse immunitaire à médiation assurée par des cellules tueuses naturelles contre la cellule lors de la transplantation chez un sujet récepteur. Les cellule selon l'invention expriment une molécule immuno-régulatrice sur la surface des cellules ou sécrètent la molécule immuno-régulatrice sous forme soluble. Elles peuvent être transplantées chez un sujet receveur de telle sorte que le rejet de la cellule soit inhibé. L'invention s'attache par ailleurs à décrire des animaux transgéniques non-humains qui renferment des cellules qui ont été génétiquement modifiées pour exprimer moins une molécule immuno-régulatrice.

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