C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/09 (2006.01) C12N 15/82 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2481656
A cell in which the activity of a protein participating in the transport of an intracellular sugar nucleotide GDP-fucose into Golgi bodies is depressed or deleted compared with its parent strain cells; a process for producing an antibody composition with the use of the above cell; a transgenic nonhuman animal or plant the genome of which has been modified so as to depress or delete the activity of a protein participating in the transport of an intracellular sugar nucleotide GDP-fucose into Golgi bodies, or offspring thereof; a process for producing an antibody composition from the above animal or plant; and a drug containing the antibody composition.
L'invention porte sur une cellule dans laquelle l'activité d'une protéine participant au transport intracellulaire d'un GDP-fucose d'un nucléotide du sucre dans les appareils de Golgi est inhibée ou supprimée en comparaison de ses cellules souches parents. L'invention porte également sur un procédé de production d'une composition d'anticorps en utilisant la cellule précitée. L'invention porte sur un animal ou un végétal transgénique dont le génome a été modifié de façon à inhiber ou supprimer l'activité d'une protéine participant au transport intracellulaire d'un GDP-fucose d'un nucléotide du sucre dans les appareils de Golgi ou de ses descendants. L'invention porte, en outre, sur un procédé de production d'une composition d'anticorps à partir de l'animal ou du végétal précité et sur un médicament contenant la composition d'anticorps.
Kanda Yutaka
Mori Katsuhiro
Satoh Mitsuo
Goudreau Gage Dubuc
Kyowa Hakko Kirin Co. Ltd.
Kyowa Hakko Kogyo Co. Ltd.
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