C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 35/12 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2742698
The present invention relates to cells capable of expressing IDO, nucleic acid constructs for expression of IDO, cells comprising said constructs and methods of utilizing said cells in the treatment of diseases. In particular the present invention relates to cells which expresses IDO in the absence of exposure to IFN-gamma, and to their use in preparation and/or generation of immunomodulatory cells specific for an antigen.
La présente invention porte sur des cellules capables d'exprimer IDO, des produits de construction d'acide nucléique pour exprimer IDO, des cellules comprenant lesdits produits de construction et des méthodes d'utilisation desdites cellules dans le traitement de maladies. En particulier, la présente invention porte sur des cellules qui expriment IDO en l'absence d'une exposition à IFN-gamma, et sur leur utilisation dans la préparation et/ou la génération de cellules immunomodulatrices spécifiques d'un antigène.
Buescher Dirk
de La Rosa Olga
Lombardo Eleuterio
Cellerix S.a.
Gowling Lafleur Henderson Llp
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