Cells of which genome is modified

Details Cells of which genome is modified Cells of which genome is modified

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2481657

Cells wherein the genome has been modified so that the activity of an enzyme relating to the sugar chain modification of binding the 1-position of fucose to the 6-position of a N-acetylglucosamine at the reducing end of a complex N- glycoside linked sugar chain via an .alpha.-bond is lowered, compared with the activity in the parent strain cells, or deleted; and a process for producing an antibody composition using these cells.

La présente invention concerne des cellules dont le génome a été modifié de sorte que l'activité d'une enzyme se rapportant à la modification de la fixation d'une chaîne glucidique à la position 1 du fucose à la position 6 d'un N-acétylglucosamine au niveau de l'extrémité réductrice d'une chaîne glucidique liée au complexe N-glycoside via une liaison .alpha., est diminuée, comparé à l'activité dans les cellules souches mères, ou supprimée. L'invention concerne également un procédé de production d'une composition d'anticorps faisant appel auxdites cellules.

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