Cellubrevin homologs

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2216147

The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflammed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.

La présente invention concerne des séquences de nucléotides et d'acides aminés identifiant et codant de nouvelles cellubrévines (CB). La présente invention concerne également des molécules anti-sens par rapport aux séquences de nucléotides codant les CB, des vecteurs d'expression destinés à la production de CB purifiées, des anticorps capables de se lier spécifiquement aux CB, des sondes d'hybridation ou des nucléotides permettant de détecter l'induction de séquences de nucléotides codant les CB, des cellules hôtes créées génétiquement et destinées à l'expression de CB, des tests faisant appel à des molécules d'acide nucléique codant les CB et destinés au diagnostic de cellules et/ou de tissus activés, enflammés ou malades, et, enfin, des anticorps capables de se lier spécifiquement aux CB.

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