Cellular attachment to laminin 5-coated trans-epithelial...

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61K 6/00 (2006.01) A61L 27/22 (2006.01) A61L 27/34 (2006.01) A61L 27/38 (2006.01) A61L 29/00 (2006.01) A61L 29/08 (2006.01) A61L 31/00 (2006.01) A61L 31/10 (2006.01)

Patent

CA 2250215

A trans-epithelial appliance or shaped article coated with laminin 5. Laminin 5 stimulates cell attachment and may comprise an insoluble or soluble cell matrix. The appliance will be useful for reducing inflammation and/or infection at the site of entry of the appliance. The appliance may also be used to stimulate gum junctional epithelium adhesion in the treatment of, for example, gingivitis and periodontitis.

L'invention concerne un dispositif trans-épithélial ou article profilé recouvert de laminine 5. La laminine 5 stimule la fixation des cellules et peut être incluse dans une matrice cellulaire insoluble ou soluble. Le dispositif peut être utilisé pour réduire une inflammation et/ou infection sur son site d'introduction. Il peut également être utilisé pour stimuler l'adhésion de l'épithélium jonctionnel sur la gencive dans le traitement, par exemple, de la gingivite et de la desmodontite.

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