Cellular compositions for use in therapy

Details Cellular compositions for use in therapy Cellular compositions for use in therapy

A - Human Necessities

01

N

A01N 1/02 (2006.01) A61L 27/38 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2745539

The present invention provides a therapeutic composition comprising: (i) Trolox, Na+, K+, Ca2+, Mg2+' Cl-, H2PO4-, HEPES, lactobionate, sucrose, mannitol, glucose, dextran-40, adenosine, glutathione; and (ii) stem cells or progenitor cells, wherein the composition does not comprise a dipolar aprotic solvent, in particular DMSO. The present invention also relates to methods of formulating said composition for cryopreservation and subsequent direct administration to a patient, and medicaments comprising said composition.

La présente invention porte sur une composition thérapeutique, comprenant : (i) du Trolox, du Na+, du K+, du Ca2+, du Mg2+, du Cl-, du H2PO4 -, de l'HEPES, du lactobionate, du saccharose, du mannitol, du glucose, du dextran-40, de l'adénosine, de la glutathione; et (ii) des cellules souches ou des cellules parentes, la composition ne comprenant pas de solvant aprotique dipolaire, en particulier du DMSO. La présente invention porte également sur des procédés de formulation de ladite composition en vue de sa cryopréservation et sur son administration directe ultérieure à un patient, ainsi que sur des médicaments comprenant ladite composition.

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