Cellular depolarization and regulation of matrix...

Details Cellular depolarization and regulation of matrix... Cellular depolarization and regulation of matrix...

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 31/14 (2006.01) A61K 31/407 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2536247

A mechanism is disclosed wherein depolarization of the cells associated with disease states, wherein matrix metalloproteinases are implicated as a contributor to the pathology of the disease state, and the subsequent regulation of certain proteins beneficially aids control of the matrix metalloproteinases. This initiating trigger can ultimately result in the down- regulation or up-regulation of matrix metalloproteinases . An example is given wherein matrix metalloproteinase 2 (MMP 2) is down-regulated.

L'invention concerne un mécanisme de dépolarisation de cellules associées à des états pathologiques, les métalloprotéinases contribuant auxdits états pathologiques. La régulation ultérieure de certaines protéines permet de contrôler avantageusement les métalloprotéinases matricielles. Ce déclenchement initial peut avoir pour effet une régulation positive ou négative des métalloprotéinases matricielles. Un mode de réalisation constitue un exemple de régulation négative de métalloprotéinases matricielles 2 (MMP2).

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