Cellular injury response element and uses thereof

Details Cellular injury response element and uses thereof Cellular injury response element and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2258553

The present invention provides a vector with a DNA sequence coding for a cellular injury element promoter from nucleotides -74 to -35 of the GADD153 promoter, relative to the start of transcription. The vector includes an origin of replication in operable linkage with a DNA sequence coding for the promoter. Also, a host cell is transfected with the vector and expresses the cellular injury response element promoter.

Vecteur avec séquence d'ADN codant un promoteur d'élément de réponse à la lésion cellulaire comprenant les nucléotides -74 à -35 du promoteur GADD153 à compter du début de la transcription. Ce vecteur comprend une origine de réplication réalisant une liaison avec une séquence d'ADN codant le promoteur. En outre une cellule hôte est transfectée avec le vecteur et exprime le promoteur de l'élément de réponse à la lésion cellulaire.

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