Cellular receptor for antiproliferative factor

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 31/713 (2006.01) A61P 13/10 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2658952

The present invention concerns the receptor for antiproliferative factor (APF) from bladder epithelial cells. In particular, there are compositions and methods for modulating APF, APF receptor, and/or the binding of APF to APF receptor. Agents that interfere with the binding of APF to its receptor or agents that enhance the binding of APF to its receptor are contemplated. In specific aspects, certain compositions are employed for a therapeutic purpose, such as interstitial cystitis or cancer, for example.

La présente invention concerne le récepteur du facteur antiprolifération (APF) des cellules épithéliales de la vessie. L'invention concerne, en particulier, des compositions et des procédés destinés à moduler l'APF, le récepteur de l'APF et/ou à lier l'APF au récepteur de l'APF. Des agents qui interfèrent dans la liaison entre l'APF et son récepteur ou des agents qui améliorent la liaison entre l'APF et son récepteur sont prévus. Dans des cas spécifiques, certaines compositions sont utilisées à des fins thérapeutiques, notamment contre la cystopathie interstitielle sous-muqueuse ou le cancer.

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