C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 35/14 (2006.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2258082
The present invention provides a method for enhancing the immunogenicity of weakly immunogenic or non-immunogenic cells, resulting in a cellular vaccine that can stimulate T cell activation, which in turn leads to an effective immune response. The cellular vaccines of the present invention are useful for the prevention and treatment of diseases which develop and/or persist by escaping the immune response triggered by T cell activation. Such diseases include, for example, all cancers, natural and induced immune deficiency states, and diseases caused by infections with a variety of pathogens.
La préparation invention a pour objet un procédé permettant d'améliorer l'antigénicité de cellules à antigénicité faible ou nulle, en vue d'obtenir un vaccin cellulaire capable de stimuler l'activation des cellules T, cette activation entraînant à son tour une réaction immunitaires efficace. Les vaccins cellulaires faisant l'objet de la présente invention sont utiles pour la prévention et le traitement de maladies en développement et/ou persistantes parce qu'échappant à la réaction immunitaires provoquée par l'activation des cellules T. Il s'agit par exemple de tous les cancers, d'états de carence immunitaire naturelle ou induite, et de maladies provoquées par des infections dues à divers pathogènes.
Guo Yajun
Smart & Biggar
LandOfFree
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