Cellular vesicle called ''exosome'', preparation and use...

Details Cellular vesicle called ''exosome'', preparation and use... Cellular vesicle called ''exosome'', preparation and use...

A - Human Necessities

61

K

A61K 39/00 (2006.01) C12N 5/078 (2010.01) A61K 39/12 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2296750

The invention concerns a novel method for sensitising antigen-presenting cells, novel means for implementing the method, and novel membrane vesicles with immunogenic properties. The invention concerns particularly texosomes (vesicles derived from tumour cells ) and dexosomes (vesicles derived from dendritic cells loaded with antigens or not), and their use for vectoring and presenting antigens in vitro or in vivo and methods or compositions for treating cancers, infectious, parasitic or autoimmune diseases in particular.

L'invention a pour objet un nouveau procédé de sensibilisation de cellules présentatrices d'antigène, de nouveaux moyens pour la mise en oeuvre du procédé, et de nouvelles vésicules membranaires ayant un pouvoir immunogène. L'invention concerne en particulier des texosomes (vésicules dérivées de cellules tumorales) et des dexosomes (vésicules dérivées de cellules dendritiques chargées ou non en antigènes), et leur utilisation pour la vectorisation et la présentation d'antigènes in vitro ou in vivo ainsi que dans des méthodes ou compositions pour le traitement de cancers, maladies infectieuses, parasitaires ou autoiummunes notamment.

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