A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/21 (2006.01) A61K 38/23 (2006.01)
Patent
CA 2491129
The present invention relates to methods and products for the transepithelial systemic delivery of therapeutics. In particular, the invention relates to methods and compositions for the systemic delivery of therapeutics by administering an aerosol containing antibodies or conjugates of a therapeutic agent with an FcRn binding partner to epithelium of central airways of the lung. The methods and products are adaptable to a wide range of therapeutic agents, including proteins and polypeptides, nucleic acids, drugs, and others. The methods and products have the advantage of not requiring administration to the deep lung in order to effect systemic delivery.
La pr~sente invention concerne des proc~d~s et des produits destin~s ~ l'administration syst~mique trans~pith~liale d'agents th~rapeutiques. Plus particulirement, la pr~sente invention concerne des proc~d~s et des compositions permettant l'administration syst~mique d'agents th~rapeutiques par introduction d'un a~rosol contenant des anticorps ou des conjugu~s d'un agent th~rapeutique avec un partenaire de liaison FcRn dans l'~pith~lium des voies a~riennes centrales du poumon. Les proc~d~s et les dispositifs d~crits dans cette invention peuvent s'adapter ~ une large gamme d'agents th~rapeutiques parmi lesquels les prot~ines et les polypeptides, les acides nucl~iques, les m~dicaments, etc. Ces proc~d~s et ces produits pr~sentent l'avantage de ne pas n~cessiter d'introduction en profondeur dans le poumon pour permettre l'administration syst~mique.
Bitonti Alan J.
Blumberg Richard S.
Lencer Wayne I.
Simister Neil E.
Brandeis University
Brigham And Women's Hospital Inc.
Children's Medical Center Corporation
Smart & Biggar
Syntonix Pharmaceuticals Inc.
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