Central airway administration for systemic delivery of...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 9/72 (2006.01) C12Q 1/68 (2006.01) C07K 14/735 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2479212

The present invention relates to methods and products for the transepithelial systemic delivery of therapeutics. In particular, the invention relates to methods and compositions for the systemic delivery of therapeutics by administering an aerosol containing conjugates of a therapeutic agent with an FcRn binding partner to epithelium of central airways of the lung. The methods and products are adaptable to a wide range of therapeutic agents, including proteins and polypeptides, nucleic acids, drugs, and others. In addition, the methods and products have the advantage of not requiring administration to the deep lung in order to effect systemic delivery.

L'invention concerne des procédés et des produits pour l'administration systémique trans-épithéliale de médicaments. Elle concerne, en particulier, des procédés et des compositions d'administration systémique de médicaments par apport au moyen d'un aérosol, de conjugués d'un agent thérapeutique avec un partenaire de liaison FcRn, à l'épithélium des voies aériennes centrales des poumons. Les procédés et les produits sont adaptables à un grand nombre d'agents thérapeutiques, y compris à des peptides et à des polypeptides, à des acides nucléiques, à des médicaments et à d'autres substances. Ces procédés et ces produits ont, en outre, l'avantage de ne pas nécessiter d'apport en profondeur dans les poumons afin de réaliser une administration systémique.

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