Central nervous system axon regeneration

Details Central nervous system axon regeneration Central nervous system axon regeneration

A - Human Necessities

61

K

A61K 38/43 (2006.01) A61K 35/74 (2006.01) A61K 35/76 (2006.01) A61K 38/48 (2006.01) C07K 14/33 (2006.01) C12N 9/10 (2006.01) G01N 33/50 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2300878

Therapies for the treatment of a variety of central nervous system injuries including acute or chronic spinal cord injury, traumatic brain injury, and white matter stroke involve the administration of rho protein inhibitors to promote axon regeneration. Local administration is employed in typical embodiments, and this may include injection of a recombinant virus that expresses an inhibitor. In one embodiment, the inhibitor is C. botulinium C3 exoenzyme or a chimeric C. botulinum C2/C3 construct expressed in a replication-deficient adeno, adeno-associated, or herpes virus.

Des thérapies permettant de traiter diverses lésions du système nerveux central y compris les lésions médulaires aigues ou chroniques, les lésions chromatiques du cerveau et les accidents vasculaires atteignant la substance blanche implique l'administration d'inhibiteurs de protéine rho pour activer la régénération des axones. Dans des formes de réalisations classiques, on utilise l'administration locale, cette dernière pouvant comprendre l'injection d'un virus de recombinaison qui exprime un inhibiteur. Dans une forme de réalisation, l'inhibiteur est la l'exoensyme C3 C.botulinium ou une structure C2/C3 C.botulinum chimérique exprimée dans un virus adéno déficient au niveau de la réplication, un virus adéno associé ou un virus associé.

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