C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 4/12 (2006.01) A61K 38/03 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2264959
The present invention is directed to a central nervous system-derived heat stable immune privilege factor which exerts an inhibitory effect on macrophage migration and/or macrophage phagocytic activity. In addition, the factor exerts an inhibitory effect on the ability of macrophages and T cells to adhere to extracellular matrix and/or fibronectin. The invention is also directed to the isolation and methods for use of this immune privilege factor for the inhibition of inflammation in the central nervous system generally and at specific lesions in the central nervous system.
L'invention concerne un facteur d'immunisation privilégiée thermostable, dérivé du système nerveux central, qui a un effet inhibiteur sur la migration des macrophages et/ou l'activité phagocytique des macrophages. En outre, ledit facteur exerce un effet inhibiteur sur la capacité des macrophages et des cellules T à adhérer à la matrice extracellulaire et/ou la fibronectine. L'invention se rapporte également à l'isolation et à de procédés d'utilisation dudit facteur d'immunisation privilégiée, destinés à inhiber l'inflammation du système nerveux central ou de points de lésions spécifiques du système nerveux central.
Beserman Pierre
Eisenbach-Schwartz Michal
Hirschberg David L.
Ltd. Yeda Research And Development Co.
Smart & Biggar
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