Central venous catheters loaded with lipodalbaheptide...

Details Central venous catheters loaded with lipodalbaheptide... Central venous catheters loaded with lipodalbaheptide...

A - Human Necessities

61

L

A61L 29/00 (2006.01) A61L 31/00 (2006.01) A61M 25/00 (2006.01)

Patent

CA 2106901

The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with a lipodalbaheptide antibiotic and the method for their preparation. Lipodalbaheptide antibiotics particularly suitable for the preparation of the above mentioned central venous catheters are selected from teicoplanin, its functional derivatives at the C-63 carboxy group, antibiotic A 40926, and its derivatives at the C-63 carboxy group. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of selected lipodalbaheptide antibiotic.

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