Cephalosporin antibiotics

Details Cephalosporin antibiotics Cephalosporin antibiotics

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/36 (2006.01)

Patent

CA 1122973

ABSTRACT OF THE DISCLOSURE Cephalosporin antibiotics of general formula: Image (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group, and Y represents a C-linked 5- or 6-membered heterocyclic ring containing at least one nitrogen atom, which ring may also contain one or more sulphur atoms and/or may be substituted by a C1-4 alkyl group) exhibit broad spectrum antibiotic activity, the activity being unusually high against gram-negative organisms such as strains of Pseudomonas organisms. Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics.

328415

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