Cephalosporin antibiotics

Details Cephalosporin antibiotics Cephalosporin antibiotics

C - Chemistry, Metallurgy

07

D

C07D 501/59 (2006.01) A61K 31/545 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07D 277/38 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 501/00 (2006.01) C07D 501/18 (2006.01) C07D 501/24 (2006.01) C07F 7/10 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2234255

The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem- 4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to .beta.-lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.

L'invention porte sur de nouveaux acides (7R)-7-(acylamino)-3-(arylthio)-3-céphem-4-carboxyliques ou leurs sels pharmacocompatibles qui présentent une activité antibiotique contre un large spectre d'organismes, dont ceux qui résistent aux antibiotiques du type .beta.-lactame, et s'avèrent d'utiles agents antibactériens. L'invention porte également sur de nouveaux intermédiaires de fabrication desdits composés et sur de nouveaux procédés d'obtention desdits composés et intermédiaires.

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