C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/104.1
C07D 501/46 (2006.01) C07D 277/20 (2006.01)
Patent
CA 1130280
ABSTRACT OF THE DISCLOSURE Cephalosporin antibiotics of general formula Image (I) (wherein R and Rb, which may be the same or different, each represent a Clue alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group; and R1 represents a C1-4 alkyl group) exhibit broad spectrum antibiotic activity with unusually high activity against strains of Psendomonas organisms as well as high activity against various members of the Enterobacteriaceae. The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics.
338576
Ayres Barry E.
Livermore David G.h.
Newall Christopher E.
O'callaghan Cynthia H.
Sutherland Derek R.
Fetherstonhaugh & Co.
Glaxo Group Limited
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