C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/104.1
C07D 501/46 (2006.01) C07D 277/20 (2006.01)
Patent
CA 1131618
ABSTRACT OF THE DISCLOSURE Cephalosporin antibiotics of general formula Image (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group; and R1, R2 and R3, which may be the same or different, each represents a C1-4 alkyl group) exhibit broad spectrum antibiotic activity with unusually high activity against strains of Pseudomonas organisms as well as high activity against various members of the Enterobacteriaceae. The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics.
338568
Ayres Barry E.
Livermore David G.h.
Newall Christopher E.
O'callaghan Cynthia H.
Sutherland Derek R.
Fetherstonhaugh & Co.
Glaxo Group Limited
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