Cephalosporin compounds

Details Cephalosporin compounds Cephalosporin compounds

C - Chemistry, Metallurgy

07

D

260/102, 260/103

C07D 501/20 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 1122972

ABSTRACT OF THE DISCLOSURE A process for the preparation of a 3-carba- moyloxymethyl cephalosporin compound comprises reacting a 3-hydroxymethyl cephalosporin with dihalophosphinyl isocyanate and converting the resulting 3-phosphonocarbamoyloxymethyl cephalo- sporin reaction product by hydrolysis to the desired compound. The isocyanates used in the process are readily available and easy to handle and thus the process avoids the use of hazardous and/or expensive reagents.

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