Cephalosporin compounds and antibacterial agents

Details Cephalosporin compounds and antibacterial agents Cephalosporin compounds and antibacterial agents

C - Chemistry, Metallurgy

07

D

167/187, 260/104

C07D 501/20 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01)

Patent

CA 1339417

Novel cephalosporin compounds of the formula (I): (see fig. I) wherein R1 and R2 may be the same or different and are a hydrogen atom, a lower alkyl group or a phenyl group and A is (1) hydrogen atom, (2) a hydroxyl group, (3) an azido group, (4) an acetoxy group, (5) a pyridinium group, which may be substituted by a straight-chain, a branched-chain or a cyclic alkylthio group having 1-5 carbon atoms or a carbamoyl group, or (6) an isoquinolinium-2-yl group or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.

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