Cephalosporin compounds and process for preparing the same

C - Chemistry – Metallurgy – 07 – D

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260/104.1

C07D 501/36 (2006.01) C07C 45/71 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 213/85 (2006.01)

Patent

CA 1148142

ABSTRACT OF THE DISCLOSURE Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) Image (I) wherein R1 and R2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubsti- tuted phenylalkoxy group; R3 represents hydrogen or a lower alkyl group; R4 represents hydrogen or a hydroxyl group; and R5 represents Image , Image , Image , Image , Image or Image wherein R6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a -(CH2)n-SO3Na group, or a -(CH2)n-COR9 group [wherein R9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an Image group, (wherein R10 and R11, which may be the same or different, can represent hydrogen or an alkyl group], and n is 0 or an integer of from 1 to 4; R7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.

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