Cephalosporin compounds and processes for preparation thereof

Details Cephalosporin compounds and processes for preparation thereof Cephalosporin compounds and processes for preparation thereof

C - Chemistry, Metallurgy

07

D

C07D 501/36 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2088926

2088926 9203445 PCTABS00010 The present invention provides a cephalosporin compound represented by formulas (I-S) and (I-R), wherein R1 is a C1-4 alkyl, C3-4 alkenyl, C3-4 cycloalkyl, amino optionally substituted with a C1-4 alkyl radical, phenyl, or 2-, 4- or 6- substituted phenyl group with two or fewer substituents chosen from C1-4 alkyl, C1-3 alkoxy, halogen and hydroxy radicals; R2 is hydrogen or a C1-4 alkyl group; Ra and Rb, which should be different from each other, are hydrogen or a C1-4 alkyl group; and Q is N or CH, and the pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates thereof, which possess potent and broad antibacterial activities. The invention also provides processes for preparing these compounds and to pharmaceutical compositions containing them as active ingredients.

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