Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

C - Chemistry, Metallurgy

07

D

260/101, 167/187

C07D 501/18 (2006.01) A61K 31/545 (2006.01) C07C 45/79 (2006.01) C07D 285/08 (2006.01) C07D 519/06 (2006.01)

Patent

CA 1340638

7-(2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(substituted)- iminoacetamido]-3-[3-(quaternaryammonio)-1-propen-1-yl]-3-cephem- 4-carboxylates of the formula (see fig. I) in which R1 and R2 are as defined herein and ~N~Q is a quaternary ammonio group as defined herein, and salts, solvates, hydrates and esters thereof, are potent antibacterial agents. Processes for their preparation and intermediates in such processes are described.

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