Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

C - Chemistry, Metallurgy

07

D

C07D 501/48 (2006.01) A61K 31/545 (2006.01) A61K 31/695 (2006.01) C07D 213/70 (2006.01) C07D 401/04 (2006.01) C07D 501/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2174476

Novel cephem derivatives represented by the general formula Image in which the Acyl substituent is a group of the formula Image wherein Ar is a lipophilic optionally substituted phenyl, naphthyl or pyridyl group; R1 represents either the residue of a heterocyclic amino acid or a C2-C10 alkyl group substituted by both a carboxyl group and a group of the formula -NR9R10 or Image in which R9 and R10 are each independently hydrogen or C1-C6 alkyl, said C2-C10 alkyl group being optionally interrupted by one or more nitrogen atoms or carbonyl groups, and R2 and R3 are each independently hydrogen, alkyl or aminoalkyl are gram-positive antibacterial agents, especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus (also referred to below as MRSA or methicillin- resistant S. aureus).

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