Cephalosporin derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 501/16 (2006.01) C07D 501/00 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2157870

A cephalosporin derivative represented by the following general formula Image (I) (R1: a hydrogen atom, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group, an protective group for the hydroxyl group or a substituted or unsubstituted lower alkyl group, R2: a hydrogen atom, an ester residue or a negative charge, R3: (1) a group represented by the following formula Image R4, R5: the same or different from each other and each represents a lower alkoxy group or a substituted or unsubstituted amino group, or R4 and R5 may be combined together with the neighboring tetrahydropyridazine ring to form a substituted or unsubstituted condensed five- or six- membered cyclic group, or (2) a group represented by the following formula Image or Image R6, R7: the same or different from each other and each represents a hydrogen atom, a halogen atom, an amino group, an azide group, a carbamoyl group, an unsubstituted or amino-, azide-, carbamoyl- or halogen-substituted lower alkyl group, a carbamoyl group or a substituted or unsubstituted five- or six-membered heterocyclic group (nitrogen atom of the hetero ring may be substituted to form a quaternary amine together with substituent groups), X: a methine group (-CH=) or a nitrogen atom, and A ring: a four- or five-membered nitrogen-containing hetero ring which may contain an oxygen atom), or a salt thereof.

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