Cephalosporin derivatives and antibiotics containing the same

Details Cephalosporin derivatives and antibiotics containing the same Cephalosporin derivatives and antibiotics containing the same

C - Chemistry, Metallurgy

07

D

167/187, 260/104

C07D 501/36 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01)

Patent

CA 1281712

ABSTRACT OF THE DISCLOSURE New cephalosporin derivatives of a general formula (I) and non-toxic salts and non-toxic esters thereof are provided: (I) Image (wherein R represents an acyclic or cyclic lower alkyl group having 1-6 carbon atoms, which may optionally be substituted by a halogen atom; the steric configuration as asterisked (*) includes an optical-active (R)-form or (S)-form or an optical-inactive (RS)-form; n is O or 1, n1 is 0 to 3, n2 is 0 to 3; and when n1 is 0, n2 is 3; when n1 is 1, n2 is 2; when n1 is 2, n2 is 1; when n1 is 3, n2 is 0). The new derivatives of the formula (I) and non- toxic salts and esters thereof have high bactericidal activity with broad antibacterial spectra, and these are useful as active ingredients in bactericides.

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