Cephalosporin salts and process for the preparation thereof

Details Cephalosporin salts and process for the preparation thereof Cephalosporin salts and process for the preparation thereof

C - Chemistry, Metallurgy

07

D

C07D 501/24 (2006.01) A61K 31/545 (2006.01) C02F 1/469 (2006.01) C07D 333/40 (2006.01) C07D 501/00 (2006.01) C07D 501/57 (2006.01) C02F 1/20 (2006.01) C02F 1/28 (2006.01) C02F 1/42 (2006.01) C02F 1/44 (2006.01)

Patent

CA 2112196

- 1 - Abstract of the disclosure Cephalosporin salts and process for the preparation thereof The invention relates to cephalosporin salts of the formula (I) [cephalosporin]m.theta. x[BxH+]?n (I) wherein the salt-forming anion is an antibiotically active cephalosporin with one group (m = 1) capable of anion formation ox else a plurality of groups of this type (m = 2 or 3), and the base, which can be present as the pure (+)- or (-)-enantiomer or in the racemic form, is of the formula (B) Image (A) where R1 is straight-chain or branched alkyl having 1-8 carbon atoms, which is unsubstituted or substituted by hydroxyl, phenyl or by phenyl substituted by alkoxy or halogen, preferably a methyl, ethyl, propyl, butyl or benzyl group, R2, R3, R4 and R5 can be identical or different and are hydrogen or straight-chain or branched alkyl having 1-4 carbon atoms, with preferably R2 being propyl, R3 and R4 being methyl and R5 being hydrogen, and m and n are, depending on the number of the salt-forming groups in the cephalosporin moiety, a number from 1 to 3 in the case of m, preferably 1 and 2, and in - 2 - the case of n 0, 1 to 3, preferably 0, 1 to 2. The cephalosporin salts according to the invention have good antibacterial activity and can therefore be used as medicaments.

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