A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/187
A61K 31/545 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01)
Patent
CA 1043261
ABSTRACT OF THE DISCLOSURE A stable form of sodium 7-(D-2-formyloxy-2-phenyl- acetamido)-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem- 4-carboxylate is prepared by a process which comprises the steps of (a) reacting 7-(D-2-formyloxy-2-phenylacetamido)- 3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylic acid with a sodium salt of an organic acid in the presence of an organic solvent; (b) separating the sodium 7-(D-2-formyloxy-2-phenyl- acetamido)-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem- 4-carboxylate in dry form from the reaction mixture, optionally recrystallized, and dried; and (c) blending the dry sodium 7-(D-2-formyloxy-2-phenyl- acetamido)-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem- 4-carboxylate with between about 0.1 mole and 1.2 moles of an alkali metal carbonate or tris(hydroxymethyl)aminomethane per mole of said sodium 7-(D-2-formyloxy-2-phenylacetamido)-3- (1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylate salt. Aqueous solutions of this medicament remain clear and colorless on standing (in contrast to aqueous solutions of the above cephalosporin antibiotic compound alone, which develop turbidity on standing), and therefore are suitable for I.V. solutions. The antibiotic is of value in treating bacterial infections.
220537
Greene James M.
Indelicato Joseph M.
LandOfFree
Cephalosporin-type antibiotic composition does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cephalosporin-type antibiotic composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cephalosporin-type antibiotic composition will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1033099