Cephalosporins

Details Cephalosporins Cephalosporins

C - Chemistry, Metallurgy

07

D

260/104.5

C07D 501/36 (2006.01) C07D 271/08 (2006.01) C07D 277/56 (2006.01)

Patent

CA 1062701

ANTIBACTERIAL AGENTS Abstract of the Disclosure 7-[D-(.alpha.-Amino-a-phenyl-, 2-thienyl-and 3-thienylacetamido]-3-(thiazol-2-yl)carbonyl- thiomethyl-3-cephem-4-carboxylic acid and 7-[D-(.alpha.-amino-a-phenyl-, 2-thienyl- and 3- thienylacetamido]-3-(5-methylthiazol-2-yl)carbon- ylthiomethyl-3-cephem-4-carboxylic acid and 7-[D-(.alpha.-Amino-.alpha.-phenyl-, 2-thienyl- and 3- thienylacetamido]-3-(3-methyl-1,2,5-oxadiazol-4-yl)- carbonylthiomethyl-3-cephem-4-carboxylic acids and their pharmaceutically acceptable salts are valuable as antibacterial agents, as nutritional supplements in animal feeds, as agents for the treatment of mastitis in cattle and as therepeutic agents in poultry and animals, including man. The compounds are especially useful in the treat- ment, particularly by oral administration, of infectious diseases caused by many Gram-positive and Gram-negative bacteria. Also included within the invention are easily cleavable esters of the above acids and pharmaceutically acceptable acid addition salts of said esters. - 1 -

231504

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