Cephalosporins

Details Cephalosporins Cephalosporins

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/46 (2006.01) A61K 31/545 (2006.01) C07D 501/04 (2006.01) C07D 501/44 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1074297

ABSTRACT OF THE DISCLOSURE Cephalosporin antibiotics in which the 7.beta.-acylamido group has the formula Image (where R1 is furyl or thienyl and R2 is C1-4 alkyl, C3-7 cycloalkyl, furylmethyl or thienylmethyl) and in which the 3-position substituent is a pyridiniummethyl group wherein the pyridine ring is optionally substituted by carbamoyl, carboxy, carboxymethyl, sulpho or methyl exhibit high antibacterial activity against a broad range of gram-positive and gram-negative organisms, coupled with particularly high stability to .beta.-lactamases produced by various gram-negative organisms and good stability in vivo, particularly to esterases.

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