Cephalosporins

Details Cephalosporins Cephalosporins

C - Chemistry, Metallurgy

07

D

260/106.1

C07D 501/20 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/22 (2006.01) C07D 501/24 (2006.01) C07D 501/26 (2006.01) C07D 501/28 (2006.01) C07D 501/34 (2006.01) C07D 501/36 (2006.01) C07D 501/38 (2006.01) C07D 501/46 (2006.01) C07D 501/56 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1127149

Abstract of the disclosure: A novel cephalosporin derivative of the formula: Image [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula -SR1 (where R1 is a nitrogen-containing heterocyclic group)] or a pharmaceu- tically acceptable salt or ester thereof is found to have potent antibiotic activity against various bacteria, par- ticularly against gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri and Citrobacter freundii.

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