Cephalosporins

Details Cephalosporins Cephalosporins

C - Chemistry, Metallurgy

07

D

260/100, 167/187

C07D 519/00 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 513/04 (2006.01) A61F 15/00 (2006.01)

Patent

CA 2031008

Abstract Novel cephalosporins of the formula Image (I) in which R1 - represents halogen or - represents straight-chain or branched alkyl, alkyl- thio or alkenyl having up to 10 carbon atoms, which is optionally substituted by halogen, straight- chain or branched alkoxy having up to 8 carbon atoms or by a 5-membered unsaturated heterocycle having up to 4 heteroatoms from the group consisting of nitrogen and sulphur, which for its part may be substituted by straight-chain or branched alkyl or alkylaminodi- alkyl having up to 6 carbon atoms, - or which is optionally substituted by a group of the formula -OCOR2, in which R2 - denotes amino or straight-chain or branched alkyl having up to 6 carbon atoms, - represents straight-chain or branched alkoxy having up to 8 carbon atoms, - represents a group of the formula -CH2-S-R3, in which R3 - denotes a 5-membered unsaturated heterocycle having up to 4 heteroatoms from the group consisting of nitrogen and sulphur, which is optionally substituted by straight-chain or branched alkyl or alkylaminodialkyl having up to 6 carbon atoms, and Abstract (continued) X - represents oxygen, sulphur or the radical -NH, and their physiologically acceptable salts. Novel intermediates are also shown.

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