Cephalosporins having an .alpha.-acylaminoacetic acid side...

Details Cephalosporins having an .alpha.-acylaminoacetic acid side... Cephalosporins having an .alpha.-acylaminoacetic acid side...

C - Chemistry, Metallurgy

07

D

260/104.1, 260/1

C07D 501/20 (2006.01) C07D 285/135 (2006.01)

Patent

CA 1076103

Abstract of the Disclosure Compounds of the formula Image wherein R1 denotes optionally substituted phenyl, thienyl, furyl or 1,4-cyclohexadienyl, R2 represents a free carboxyl group or an esterified carboxyl group which can be split physiologically, R3 represents hydrogen, lower alkoxy or an optionally substituted methyl group and B represents an optionally substituted six-membered ring with 1 to 3 ring nitrogen atoms, which is bonded to the carbonyl group -C(=O)- by one of its carbon atoms, the nitrogen atoms of a mono- cyclic six-membered ring having 2 nitrogen atoms being either adjacent or separated by two ring carbon atoms, and the salts of such compounds which have a salt-forming group, including the inner salts, for example the 7.beta.-[D(-)-.alpha.-(3,5-Dioxo-2,3,4, 5-tetrahydro-1,2,4-triazine-6-carboxamido)-phenylacetamido)- cephalosporanic acid, have antibiotic activity.

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