C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/100, 260/104
C07D 501/20 (2006.01) C07D 241/18 (2006.01) C07D 405/04 (2006.01)
Patent
CA 1253486
ABSTRACT OF THE DISCLOSURE Intermediates in the product of cephalosporine in which a substituted or unsubstituted 2,3-dioxo-1,2,3,4- tetrahydropyrazinyl, 2-oxo-1,2-dihydropyrazinyl, 3,6-dioxo- 1,2,3,6-tetrahydropyridazinyl or 6-oxo-1,6-dihydropyridazinyl group is attached to the exomethylene group at the 3-position of the cephem ring through a carbon-nitrogen bond and which have the following group attached to the amino group at the 7-position: Image wherein -A- represents a group of the formula, -CH2- or a group of the formula, Image in which R18 represents a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aralkyl, aryl, heterocyclic group or a hydroxyl-protecting group or a group of the formula: Image (each of R19 and R20), which may be the same or different, represents a hydroxyl, alkyl, aralkyl, aryl, alkoxy, aralkyloxy or aryloxy group), and the bond means that the compound may be a syn-isomer or an anti-isomer or a mixture thereof; R4 represents a hydrogen atom or a halogen atom; and R5 represents a hydrogen atom or a protected or unprotected amino group. These cephalosporins have a broad antibacterial spectrum, are stahle against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.
441286
Fukuoka Yoshikazu
Imaizumi Hiroyuki
Inaba Takihiro
Minami Shinzaburo
Myokan Isao
Marks & Clerk
Toyama Chemical Co. Ltd.
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