C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/100
C07D 501/20 (2006.01) A61K 31/545 (2006.01)
Patent
CA 1204735
ABSTRACT OF THE DISCLOSURE Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: Image wherein A represents a group of the formula, -CH2- or a group of the formula Image in which R5 represents a hydrogen atom or an alkyl group, and the bond ? represents syn or anti isomer or their mixture; R3 represents a hydrogen or halogen atom; and R represents a hydrogen atom or an amino group which may be protected or substituted. These cephalos- porins have a broad antibacterial spectrum, are stable against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally. This invention relates to such novel cephalos- porins, processes for producing said cephalosporins, intermediates for producing said cephalosporins, and a process for producing said intermediates.
386066
Hirikawa Tatsuo
Imaizumi Hiroyuki
Inaba Takihiro
Konishi Yoshinori
Narita Hirokazu
Marks & Clerk
Toyama Chemical Co. Ltd.
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