Cephapirine esters, salts thereof and processes for...

Details Cephapirine esters, salts thereof and processes for... Cephapirine esters, salts thereof and processes for...

C - Chemistry, Metallurgy

07

D

260/105.1

C07D 501/34 (2006.01) A61K 31/54 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/28 (2006.01) C07D 501/46 (2006.01)

Patent

CA 1133470

Abstract of the Disclosure The invention relates to cephapirine esters having the formula Image (I) wherein R is selected from the group consisting of Image and -CH20COC(CH3)3 Such esters and salts thereof, having antibiotic activity, are prepared by reacting 7-ACA with bromophthalide or chloromethylpivalate in the presence of an alkylamine, at a temperature in the range of 0°-70°C. The reaction compound is reacted with chlorohydrate chloride of 4-piridylthioacetic acid. A salt of the compound of formula (I) is isolated from the reaction mixture, after washing with acidic water and addition of a pharmaceutically acceptable acid, by treatment with a suitable solvent.

372958

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