Cephem compound and a process for preparation thereof

Details Cephem compound and a process for preparation thereof Cephem compound and a process for preparation thereof

C - Chemistry, Metallurgy

07

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167/187, 260/104

C07D 501/46 (2006.01) A61K 31/54 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/06 (2006.01) C07D 501/38 (2006.01) C07D 501/56 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1338842

There are described cephem compounds of the formula: Image wherein R1 is amino or a protected amino, R is lower alkyl which may have one or more suitable substituent (s), R3 is COO?, carboxy or a protected carboxy , R4 is hydroxy (lower) alkyl or protected hydroxy (lower) alkyl, R5 is amino or a protected amino, R6 is hydrogen or lower alkyl, X? is an anion, and n is 0 or 1, with proviso that (i) when R3 is COO?, then n is 0, and (ii) when R3 is carboxy or a protected carboxy, then n is 1, and pharmaceutically acceptable salt thereof. The process of producing same as well as pharma- ceutical compositions containing hte cephem compounds are also described. These compounds are highly active against a number of pathogenic microorganisms.

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