Cephem compound and a process for preparation thereof

Details Cephem compound and a process for preparation thereof Cephem compound and a process for preparation thereof

C - Chemistry, Metallurgy

07

D

167/187, 260/104

C07D 501/46 (2006.01) A61K 31/545 (2006.01)

Patent

CA 2011695

ABSTRACT Cephem compounds of the formula: Image wherein R1 is amino or a protected amino, R2 is ethyl, propyl or lower alkenyl, R3 is COO ? , carboxy or a protected carboxy, R4 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R5 is amino or a protected amino, X ? is an anion, and n is 0 or 1, or, R1, R3, R5, X ? and n are each as defined above, R2 is lower alkyl, and R4 is 3-hydroxypropyl, with proviso that (i) when R3 is COO ? , then n is 0, and (ii) when R3 is carboxy or a protected carboxy, then n is 1, or pharmaceutically acceptable salts thereof. The preparation of these compounds, pharmaceutical compositions containing then and a method of treating infectious diseases in humans and animals infected by pathogenic microorganisms are also disclosed.

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