Cephem compound, process for producing the compound, and...

Details Cephem compound, process for producing the compound, and... Cephem compound, process for producing the compound, and...

C - Chemistry, Metallurgy

07

D

C07D 501/24 (2006.01) A61K 31/545 (2006.01) A61K 31/695 (2006.01) C07D 501/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2163080

The present invention provides a cephem compound having a high antimicrobial activity against various pathogenic bacteria. The cephem compound of the invention is represented by the formula (see formula I) wherein Q represents CH or N, R1 represents a carboxylate or the like, R2 represents a hydrogen atom, and R represents (see formula II, III) wherein R3 represents a group -(CH2)m-Y (wherein m is an integer of 1 to 5, and Y represents a quaternary ammonium group) or the like, n is an integer of 0 to 4, B- represents an anion, f is 0 or 1 when R1 represents a carboxylate, and 2 when R1 represents a carboxyl group, and the ring C represents a 5-membered heterocyclic group -94- of not more than 4 nitrogen atoms, which may be substituted by a lower alkyl group.

Composé de cephem représenté par la formule générale (1), et présentant une excellente activité antibactérienne contre diverses bactéries pathogènes. Dans cette formule, Q représente CH ou N; R<1> représente carboxylate, etc.; R représente le groupe (a) ou (b); R<3> représente -(CH2)m-Y (m étant un entier de 1 à 5, et Y étant un ammonium quaternaire), etc.; n représente un entier correspondant à 0, ou de 1 à 4; B<-> représente un anion; f représente 0 ou 1 lorsque R<1> représente carboxylate, et 2 lorsque R<1> représente carboxyle; et le cycle C représente un groupe hétérocyclique à 5 éléments portant quatre atomes d'azote ou moins et pouvant être substitués par un alkyle inférieur.

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