Cephem compounds

Details Cephem compounds Cephem compounds

C - Chemistry, Metallurgy

07

D

260/101

C07D 501/16 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/06 (2006.01) C07D 501/14 (2006.01) C07D 501/18 (2006.01) C07D 501/20 (2006.01) C07D 501/24 (2006.01) C07D 501/48 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1072949

Novel Cephem Compounds Abstract of the disclosure Novel cephem compounds having a group of the formula at 3-position thereof: Image wherein X represents oxygen, sulfur or imino, which may be substituted; and B represents hydrogen or a hydroxyl, amino, mercapto or hydrocarbon group, which groups may be substituted, can be prepared by reacting a 3-formylcephem compound with a hydrazine compound of the formula: Image wherein the symbols have the same meanings as above, and subjecting the thus obtained compound to an oxidative ring-closure reaction. The objective compounds are found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia Coli Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus rettgerii, as well as gram positive ones, and have low-toxity. Thus, these compounds may be used for antimicrobial agents in therapeutical purpose. - 1 -

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