Cephem compounds and processes for preparation thereof

Details Cephem compounds and processes for preparation thereof Cephem compounds and processes for preparation thereof

C - Chemistry, Metallurgy

07

D

260/101.5

C07D 501/20 (2006.01) A61K 31/545 (2006.01) C07D 501/04 (2006.01) C07D 501/22 (2006.01) C07D 501/26 (2006.01)

Patent

CA 1112237

ABSTRACT New 7-substituted-3-cephem-4-carboxylic acid derivatives are provided of the formula: Image wherein R1 is amino or protected amino, A is lower alkylene which may be substituted with oxo, hydroxy, amino, protected hydroxy or protected amino, R2 is hydrogen, halogen or hydroxy, and R3 is carboxy or functionally modified carboxy, their nontoxic, pharmaceutically acceptable salts and bioprecursors thereof; the derivatives have antimicrobial activity against Gram negative and Gram positive bacteria.

311056

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