Cephem compounds and processes for preparation thereof

Details Cephem compounds and processes for preparation thereof Cephem compounds and processes for preparation thereof

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/46 (2006.01) C07C 17/26 (2006.01) C07D 209/48 (2006.01) C07D 257/04 (2006.01) C07D 285/08 (2006.01) C07D 295/21 (2006.01)

Patent

CA 1215969

ABSTRACT OF THE DISCLOSURE New cephem compounds and their process of preparation are provided of the formula: Image wherein R1 is amino or a protected amino group; R2 is hydrogen, lower alkyl which may be substituted with suitable substitutent(s), lower alkenyl, lower alkynyl, cyclo(lower)- alkyl, cyclo(lower)alkenyl, or O containing 5-membered heterocyclic group substituted with oxo group(s); R3 is a group of the formula: Image wherein X is hydrogen or carbamoyl; and R4 is -COO-; or R3 is 2-lower alkyl-5-oxo-6-hydroxy-2,5-dihydro-1,2,4- triazinylthio; and R4 is carboxy or protected carboxy, and pharmaceutically acceptable salts thereof; the compounds are active against a number of pathogenic micro organisms including Gram-positive and Gram-negative bacteria.

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