Cephem compounds and processes for preparation thereof

Details Cephem compounds and processes for preparation thereof Cephem compounds and processes for preparation thereof

C - Chemistry, Metallurgy

07

D

260/108, 167/187

C07D 519/00 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2029638

ABSTRACT Compounds of the formula: Image wherein R1 is amino or a protected amino group, R2 is hydrogen or an organic group, R3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, arnino(lower)alkyl, protected amino(lower)alkyl, carbamoyl(lower)alkyl, N,N-di(lower)alkylcarbamoyl(lower)alkyl or an imino protective group, R4 is hydrogen, lower alkyl, carboxy, protected carboxy, amino, protected amino or carbamoyl, and Z is N or CH, and a pharmaceutically acceptable salt thereof. These compounds exhibit high antimicrobial activity and inhibit the growth of a wide variety of pathogenic microorganisms including Gram-positive and Gram-negative microorganisms. They are use- ful as antimicrobial agents. They are useful for treating infectious diseases caused by pathogenic microorganisms. The preparation of these compounds, pharmaceutical compositions containing them, and medical treatment with these compositions are also disclosed.

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